Association of Hyperhomocysteinemia and Coronary Heart Disease in South Indian Population

Mccully first reported association of elevated levels of homocysteine with vascular disease. It was later confirmed by Wilken and Wilken in a case-control study. Development of aggressive, premature vascular disease with homocystinuria led to the hypothesis that mild to moderate elevations in plasma homocysteine might contribute to the development and progression of atherosclerosis in adults. Reduction of cardiovascular risk in homocystinuric patients with dietary methionine restriction and B vitamin supplementation suggested a causal role of higher levels of homocysteine in vascular pathology of homocystinuria.