The Indian Journal of Nutrition and Dietetics

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Molecular Docking and Therapeutic Targets of Flavanol Compounds from Camellia Sinensis on Alzheimer’s Disease


Affiliations
1 Department of Biochemistry, Biotechnology and Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641 043, Tamil Nadu, India
     

   Subscribe/Renew Journal


Alzheimer’s disease is a progressive neurodegenerative disorder with neuropsychiatric symptoms and several cognitive functions and is biochemically characterized by a significant decrease in the brain neurotransmitter acetylcholine. The current study is performed to investigate possible interaction of the active components identified from Camellia sinensis (Green tea) with acetyl cholinesterase (AChE) through docking studies using Schrödinger software (Maestro V: 11.8 Schrödinger_suite-2019). In silico study results clearly showed that catechin and epicatechin-3-gallate binds effectively with AChE through strong hydrogen bonding.

Keywords

Alzheimer’s Disease, Acetylcholinesterase, Catechin, Epicatechin-3-gallate, Docking, Camellia Sinensis
User
Notifications

  • Ashraf, A., Stosnach, H., Parkes, H.G., Hye, A. and Powell, J. Wah So, P. and Neuromed consortium. Patterns of Altired Plasma Eelimental Phosphorus Calcium, Zinc and Iron in Alzheimer’s Disease. Sci. Rep., 2019, 28, 3147.

  • Hussain, G., Zhang, L., Rasul, A., Anwar, H., Sohail, M.U., Razzaq, A., Aziz, N., Shabbir, A., Ali, M. and Sun, T. Role of plant-derived flavonoids and their mechanism in attenuation of Alzheimer’s and Parkinson’s diseases: An update of recent data, Molecules, 2018, 23, 1-26.

  • Feng, X., Wang, X., Liu, Y. and Di, X.L. Inhibits the Acetylcholinesterase activity In-vitro and Ex-vivo. Iran. J. Pharm. Res., 2015, 14, 949-954. PMCID: PMC4518125

  • Mohideen. A.P. In silico identification of novel immunostimulating phytochemicals with acetylcholinesterase inhibition activity from Piper betle L. and Vitex negundo L. for the treatment of Alzheimer’s disease (AD). Ann. Phytomed., 2021, 10, 86-95. http://dx.doi.org/10.21276/ap. 2021.10.1.9

  • Jyothi, P. and Yellamma, K. Molecular docking studies on the therapeutic targets of Alzheimer’s Disease (AchE and BchE) using natural bioactive alkaloids. Inter. J. Phar. Pharm. Sci., 2016, 8, 108-112. DOI https://doi.org/10.22159/ijpps.2016v8i12.14833.

  • Malar, D.B., Shafreen, R.B., Pandian, S.K. and Devi, K.P. Cholinesterase inhibitory, anti-amyloidogenic and neuroprotective effect of the medicinal plant Grewia tiliaefolia- An in vitro and in silico study. Pharma. Bio., 2017, 55, 381-393. https://doi.org/10.1080/13880209.2016.1241811.


Abstract Views: 127

PDF Views: 1




  • Molecular Docking and Therapeutic Targets of Flavanol Compounds from Camellia Sinensis on Alzheimer’s Disease

Abstract Views: 127  |  PDF Views: 1

Authors

Nandhini Baskaran
Department of Biochemistry, Biotechnology and Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641 043, Tamil Nadu, India
Anitha Subash
Department of Biochemistry, Biotechnology and Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641 043, Tamil Nadu, India

Abstract


Alzheimer’s disease is a progressive neurodegenerative disorder with neuropsychiatric symptoms and several cognitive functions and is biochemically characterized by a significant decrease in the brain neurotransmitter acetylcholine. The current study is performed to investigate possible interaction of the active components identified from Camellia sinensis (Green tea) with acetyl cholinesterase (AChE) through docking studies using Schrödinger software (Maestro V: 11.8 Schrödinger_suite-2019). In silico study results clearly showed that catechin and epicatechin-3-gallate binds effectively with AChE through strong hydrogen bonding.

Keywords


Alzheimer’s Disease, Acetylcholinesterase, Catechin, Epicatechin-3-gallate, Docking, Camellia Sinensis

References