The Indian Journal of Nutrition and Dietetics

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Association of Vitamin B12 Status with Biochemical Parameters among the Adult Population (30 - 50 years) of Vallabh Vidyanagar, Anand, Gujarat


Affiliations
1 Post Graduate Department of Home Science, Sardar Patel University, Vallabh Vidyanagar, Anand, Gujarat - 388 120, India
     

   Subscribe/Renew Journal


Vitamin B<sub>12</sub> deficiency is known to be very common amongst the vegan population and can cause hyperhomocysteinemia due to various hematologic and neuropsychiatric disorders. Vitamin B<sub>12</sub> deficiency is a global epidemic caused by malabsorption and inadequate consumption. Vitamin B<sub>12</sub> deficiency has the greatest impact on the blood and nervous system. Elevated Methylmalonic Acid (MMA) and/or total homocysteine levels are sensitive indications of vitamin B<sub>12</sub> deficiency and have been linked to clinical problems. Hematological parameters like erythrocyte count, hemoglobin concentration or hematocrit, Mean Cell Volume (MCV), blood values such as plasma B<sub>12</sub> and the metabolite MMA are only a few examples. A total of 398 subjects, aged 30-50 years were selected from Vallabh Vidyanagar, Anand, Gujarat. Fourty two percent of the subjects were suffering from vitamin B<sub>12</sub> deficiency. The subjects were screened for their vitamin B<sub>12</sub> status and several biochemical parameters like homocysteine, iron, hemoglobin, total RBC, PCV, MCV, MCH, MCHC and RDW. Total RBC, MCV, MCH, MCHC levels, and homocysteine concentration of the subjects were found to be significantly (P ≤ 0.05) associated with the vitamin B12 status of the subjects. A positive and significant (P ≤ 0.05) relationship was observed between serum vitamin B<sub>12</sub> and iron levels (r = 0.127, P ≤ 0.05) of the subjects. In conclusion, vitamin B<sub>12</sub> status was significantly associated with total RBC, MCV, MCH, MCHC levels and homocysteine concentration.

Keywords

Vitamin B12, Homocysteine, Total RBC, MCV, MCH, MCHC
User
Notifications

  • Nakos, M., Pepelanova, I., Beutel, S., Krings, U., Berger, R.G. and Scheper, T. Isolation and analysis of vitamin B12 from plant samples. Fd. Chem., 2017, 216, 301-308.

  • Hannibal, L., Lysne, V., Bjorke-Monsen, A.L., Behringer, S., Grünert, S.C., Spiekerkoetter, U., Jacobsen, D.W. and Blom, H.J. Biomarkers and algorithms for the diagnosis of vitamin B12 deficiency. Front. Molec. Biosci., 2016, 3, 1-16.

  • Langan, R.C. and Goodbred, A.J. Vitamin B12 deficiency: Recognition and management. american family physician, 2017, 96, 384-389.

  • Moll, R. and Davis, B. Iron, vitamin B12 and folate. Med., 2017, 45, 198-203.

  • Nutrient Requirements and Recommended Dietary Allowances for Indians. Report of the Expert Group of the Indian Council of Medical Research. National Institute of Nutrition, 2010, 1-334.

  • Partearroyo, T., Samaniego-Vaesken, M. de L., Ruiz, E., Olza, J., Aranceta-Bartrina, J., Gil, A., Gonzalez-Gross, M., Ortega, R.M., Serra-Majem, L. and Varela-Moreiras, G. Dietary sources and intakes of folates and vitamin B12 in the Spanish population : Findings from the ANIBES study. PLoS ONE, 2017, 12, 1-19.

  • Green, R., Allen, L.H., Bjorke-Monsen, A.L., Brito, A., Guéant, J.L., Miller, J.W., Molloy, A.M., Nexo, E., Stabler, S., Toh, B.H., Ueland, P.M. and Yajnik, C. Vitamin B12 deficiency. Nature Rev. Dis. Primers, 2017, 3, 1-19.

  • Sun, A., Chang, J.Y.F., Wang, Y., Cheng, S., Chen, H. and Chiang, C.P. Do all the patients with vitamin B12 deficiency have pernicious anemia? J. Oral Pathol. Med., 2016, 45, 23-27.

  • Green, R. Vitamin B12 deficiency from the perspective of a practicing hematologist. Blood, 2017, 129, 2603-2611.

  • Koury, M.J. and Ponka, P. New insights into erythropoiesis: The roles of folate, vitamin B12 and iron. Ann. Rev. Nutr., 2004, 24, 105-131.

  • Mwafy, S.N. and Afana, W.M. Hematological parameters, serum iron and vitamin B12 levels in hospitalized Palestinian adult patients infected with Helicobacter pylori: A case control study. Hematol. Transfus. Cell Therap., 2018, 40, 160-165.

  • Khanna, S.P., Rigvardhan and Aggarwal, A. Correlation of serum vitamin B12 with red cell indices and hemoglobin in Indian women in second and third trimester of pregnancy. J. Med. Sci. Clin. Res., 2019, 7, 713-717.

  • Yajnik, C.S., Behere, R.V., Bhat, D.S., Memane, N., Raut, D., Ladkat, R., Yajnik, P.C., Kumaran, K. and Fall, C.H.D. A physiological dose of oral vitamin B-12 improves hematological, biochemical- metabolic indices and peripheral nerve function in B-12 deficient Indian adolescent women. PLoS ONE, 2019, 14, 1-8.

  • Prueksaritanond, S., Barbaryan, A., Mirrakhimov, A.E., Liana, P., Ali, A.M. and Gilman, A.D.A Puzzle of hemolytic anemia, iron and vitamin B12 deficiencies in a 52-year-old male. Case Rep. Hematol., 2013, 1-5.

  • Krzywański, J., Mikulski, T., Pokrywka, A., Mlyńczak, M., Krysztofiak, H., Frączek, B. and Ziemba, A. Vitamin B12 status and optimal range for hemoglobin formation in elite athletes. Nutr., 2020, 12, 1-13.

  • Ahmed, M.A. Metformin and vitamin B12 deficiency: Where do we stand? J. Pharm. Pharmace. Sci., 2016, 19, 382-398.


Abstract Views: 165

PDF Views: 1




  • Association of Vitamin B12 Status with Biochemical Parameters among the Adult Population (30 - 50 years) of Vallabh Vidyanagar, Anand, Gujarat

Abstract Views: 165  |  PDF Views: 1

Authors

Revati Shah
Post Graduate Department of Home Science, Sardar Patel University, Vallabh Vidyanagar, Anand, Gujarat - 388 120, India
Vinayak Patel
Post Graduate Department of Home Science, Sardar Patel University, Vallabh Vidyanagar, Anand, Gujarat - 388 120, India
Neeta Dave
Post Graduate Department of Home Science, Sardar Patel University, Vallabh Vidyanagar, Anand, Gujarat - 388 120, India

Abstract


Vitamin B<sub>12</sub> deficiency is known to be very common amongst the vegan population and can cause hyperhomocysteinemia due to various hematologic and neuropsychiatric disorders. Vitamin B<sub>12</sub> deficiency is a global epidemic caused by malabsorption and inadequate consumption. Vitamin B<sub>12</sub> deficiency has the greatest impact on the blood and nervous system. Elevated Methylmalonic Acid (MMA) and/or total homocysteine levels are sensitive indications of vitamin B<sub>12</sub> deficiency and have been linked to clinical problems. Hematological parameters like erythrocyte count, hemoglobin concentration or hematocrit, Mean Cell Volume (MCV), blood values such as plasma B<sub>12</sub> and the metabolite MMA are only a few examples. A total of 398 subjects, aged 30-50 years were selected from Vallabh Vidyanagar, Anand, Gujarat. Fourty two percent of the subjects were suffering from vitamin B<sub>12</sub> deficiency. The subjects were screened for their vitamin B<sub>12</sub> status and several biochemical parameters like homocysteine, iron, hemoglobin, total RBC, PCV, MCV, MCH, MCHC and RDW. Total RBC, MCV, MCH, MCHC levels, and homocysteine concentration of the subjects were found to be significantly (P ≤ 0.05) associated with the vitamin B12 status of the subjects. A positive and significant (P ≤ 0.05) relationship was observed between serum vitamin B<sub>12</sub> and iron levels (r = 0.127, P ≤ 0.05) of the subjects. In conclusion, vitamin B<sub>12</sub> status was significantly associated with total RBC, MCV, MCH, MCHC levels and homocysteine concentration.

Keywords


Vitamin B12, Homocysteine, Total RBC, MCV, MCH, MCHC

References