The Indian Journal of Nutrition and Dietetics

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Advances in Non Thermal Processing for Reducing Dairy and Food Allergenicity


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1 Department of Food science and Technology, College of Food and Dairy Technology, Chennai, India
     

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More than 160 food materials are identified as allergens. However, 90% of allergic reactions are caused by eight major food allergens. Food Allergen Labelling and Consumer Protection Act (FALCPA) of 2004 came into effect from January 1, 2006. This law requires the identification of ingredients derived from the major food allergens, on the food label. Several research efforts are ongoing to develop hypoallergenic foods. In this article, recent status of food allergy and studies reporting advanced processing technologies for reducing allergenicity of foods are reviewed. A brief survey of methods of allergen detection has been also reported as measures to control allergens in food industry.

Keywords

Food Allergy, Non-Thermal Processing, High Intensity Ultrasound, Non-Thermal Plasma, Ultraviolet Light, High Pressure Processing.
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  • El-Agamy E.I. The challenge of cow milk protein allergy. Small Ruminant Res. 2007, 68, 64-72.

  • Poms, R.E., Klein, C.L. and Anklam, E. Methods for allergen analysis in food: a review. Fd. Addit. Contam., 2004, 21, 1-31.

  • FDA. Food Allergies: What you need to know. Food Facts from the U.S. Food and Drug Administration. 2010 Available online at http://www.fda.gov/downloads/Food/ResourcesFor You/Consumers/UCM220117.pdf.

  • Monaci, L., Tregoat, V., Arjon, J., Hengel, V. and Anklam, E. Milk allergens, their characteristics and their detection in food: A review. Eur. Fd. Res. Technol., 2006, 223, 149-179.

  • Putten, M.C., Van Frewer, L.J., Gilissen, L.J.W.J., Gremmen, B., Peijnenburg, A.A.C.M. and Wichers, H.J., Novel foods and food allergy: A review of the issues. Trends. Fd. Sci. Technol., 2006, 17, 6, 289-299.

  • Derr, L. When food is poison: the history, consequences, and limitations of the Food Allergen Labeling and Consumer Protection Act of 2004. Fd. Drug. Law. J., 2006, 61, 65-165.

  • Sicherer, S.H., Munoz-Furlong, A. and Sampson, H.A. Prevalence of peanut and tree nut allergy in the United States determined by means of a random digit dial telephone survey: A 5-year follow-up study. J. Allergy. Clin. Immun., 2003, 112, 6, 1203-7.

  • Ortolani Claudio, Elide, A. and Pastorello. Food allergies and food intolerances. Best Pract Res cl ga., 2006, 20, 3, 467-483.

  • Skripak, J.M. and Wood, R.A. Peanut and tree nut allergy in childhood. Ped. Allergy. Immunol., 2008, 19, 368-373.

  • Bjorksten, B.R., Crevel, C., Hischenhuber, M., Lovik, F., Samuels, S., Strobel, S.L., Taylor, J.M. and Wal, R. Ward. Criteria for identifying allergenic foods of public health importance. Regul. Toxicol. Pharm. 2008, 51, 42-52.

  • Damodaran, S., Parkin, K.L. and Fenemma, O.R. Amino acids, peptides and proteins. In: Damodaran S. Fennemas's food chemistry. 4th ed. Boca Raton, Florida. 1996, 217-330.

  • Tanabe, S. Epitope peptides and immunotherapy. Current Protein Peptide Sci., 2007, 8, 109-18.

  • Lee, Y.H. Food-processing approaches to altering allergen. J. Pedi. Suppl., 1992, 121, 48-50.

  • Sathe, S.K., Teuber, S.S. and Roux, K.H. Effects of food processing on the stability of food allergens. Biotechnol. Adv., 2005, 23, 423-429.

  • Mondoulet, L., Paty, E., Drumare, M.F., Ah-Leung, S., Scheinmann, P., Willemot, R.M., Wal, J. M. and Bernard, H. Influence of thermal processing on the allergenicity of peanut proteins. J. Agr. Fd. Chem., 2005, 53, 4547-4553.

  • Beyer, K., Morrow, E., Li, X.M., Bardina, L., Bannon, G.A., Burks, A.W. and Sampson, H.A. Effects of cooking methods on peanut allergenicity. J. Allergy. Clin. Immunol., 2001, 107, 1077-1081.

  • Ebo, D. and Stevens, W. IgE mediated food allergy: extensive review of the literature. Acta Clin. Belg. 2001, 56, 234-247.

  • Anugu Akshay Kumar. Effect of pulsed UV lights and pulsed electric fields on selected isolated milk proteins and their allergenic properties. Master's thesis. Alabama A & M University. 2009.

  • Shanti, K.N., Martin, B.M., Nagpal, S., Metcalfe, D.D. and Rao, P.V. Identification of tropomyosin as the major shrimp allergen and characterization of its IgE-binding epitopes. J. Immunol., 1993, 151, 5354-5363.

  • Bernhisel-Broadbent, J., Dintzis, H., Dintzis, R. and Sampson, H. Allergenicity and antigenicity of chicken egg ovomucoid (Gal d III) compared with ovalbumin (Gal d I) in children with egg allergy and in mice. J. Allergy. Clin. Immunol. 1994, 93, 1047-1059.

  • Bu, G.H., Luo, Y.K., Zheng, Z. and Zheng, H. Effect of heat treatment on the antigenicity of bovine α-lactalbumin and α-lactoglobulin in whey protein isolate. Fd. Agr. Immunol., 2009, 20, 195-206.

  • Bu G., Luo Y., Chen F., Liu K. and Zhu T. Milk processing as a tool to reduce cow's milk allergenicity: A mini-review. Dairy Sci. Technol., 2013, 93, 211-223.

  • Raso, J. and Barbosa-Canovas, G. V. Non-thermal preservation of foods using combined processing techniques. Crit. Rev. Fd. Sci. Nutr. 2003, 43, 265-285.

  • Li Zhenxing, Lin Hong, Cao Limin, Jameel Khalid. Effect of high intensity ultrasound on the allergenicity of shrimp. J. Zhejiang. Univ. Sci., 2005, 7, 4, 251-256.

  • Byun, M.W., Lee, J.W., Yook, H.S., Jo, C.R. and Kim, H.Y. Application of gamma irradiation for inhibition of food allergy. Radiat. Phys. Chem., 2002, 63, 369-370.

  • Nooji Jyotsna Krishna. Reduction of wheat allergen potency by pulsed ultraviolet light, high hydrostatic pressure and non-thermal plasma. Master's thesis. University of Florida. 2011.

  • Shriver, K.S. Effect of selected non-thermal processing methods on the allergen reactivity of Atlantic white shrimp (Litopenaeus Setiferus). Master's thesis, University of Florida.2011.

  • Del Val, G., Yee, B.C., Lozano, R.M., Buchanan, B.B., Ermel, R.W., Lee, Y.M. and Frick, O.L. Thioredoxin treatment increases digestibility and lowers allergenicity of milk. J. Allergy. Clin. Immunol., 1999, 103, 4, 690-697.

  • Jedrychowski, L. and Wroblewska, B. Reduction of whey proteins by lactic acid fermentation. Fd. Agr. Immunol., 1999, 11, 91-99.

  • Shewry, P.R., Tatham, A.S. and Halford, N.G. Genetic modification and plant food allergens: risks and benefits. J. Chromat. B. Biomed. Sci. Appl., 2001, 756, 327-335.

  • Lee, J.W., Kim, J.H., Yook, H.S., Kang, K.O., Lee, S.Y., Hwang, H.J. and Byun, M.W. Effects of gamma radiation on the allergenic and antigenic properties of milk proteins. J. Fd. Prot., 2001, 64, 272-276.

  • Cho, Y., Song K.B. Effect of α-irradiation on the molecular properties of BSA and α-lactoglobulin. J. Biochem. Mol. Biol., 2000, 33, 133-137.

  • Leung Donald, Y.M. Food allergy: Are we getting closer to a cure? J. Allergy. Clin. Immunol., 2011, 127, 555-557.

  • Xenon. Sterilization and decontamination using high energy light. Woburn: Xenon corporation. 2003.

  • Krishnamurthy, K. Decontamination of milk and water by pulsed UV-light and infrared heating. PhD. dissertation, Pennsylvania State University. 2006.

  • Choudhary, R., Bandla, S., Watson, D., Haddock, J., AbuGhazaleh, A. and Bhattacharya, B. Performance of coiled tube ultraviolet reactors to inactivate Escherichia coli W1485 and Bacillus cereus endospores in raw cow milk and commercially processed skimmed cow milk. J. Fd. Eng. 2011, 107, 14-20.

  • Gennadios, A., Rhim, J.W., Handa, A., Weller, C.L. and Hanna, M.A. Ultraviolet radiation affects physical and molecular properties of soy protein films. J. Fd. Sci., 1998, 63, 2, 225-8.

  • Chung, S.Y., Yang, W. and Krishnamurthy, K. Effects of pulsed UV light on peanut allergens in extracts and liquid peanut butter. J. Fd. Sci., 2008, 73, 400-404.

  • Kolakowska, A. Lipid oxidation in food systems. In chemical and functional properties of food lipids, 2003, 133-168. Ed. New York, NY: CRC press.

  • Yang Weihua Wade, Si-Yin Chung, Olasumnbo Ajayi, Kathiravan Krishnamurthy, Koffi Konan, Renee Goodrich-Schneider. Use of pulsed ultraviolet light to reduce the allergenic potency of soybean extracts. Int. J. Fd. Eng., 2010, 3, 11.

  • Tammineedi, Effect of UV-C light, high intensity ultrasound and nonthermal atmospheric plasma treatments on the alergenicity of major cow milk proteins. M.S. Thesis, Southern Illinois University. 2013.

  • Feng, H., Barbosa-Canovas, G. and Weiss, J. Ultrasound technologies for food and bioprocessing. In food engineering series, 1st ed; Springer Science and Business Media, LLC: New York, NY. 2011.

  • Soria, A.C. and Villamiel, M. Effect of ultrasound on the technological properties and bioactivity of food: a review. Trends Fd. Sci. Technol., 2010, 21, 323-331.

  • Choudhary, R., Gautam, D., Perez-Alvarado, G. and Kinsel, M. Effect of high intensity ultrasound treatment in reducing the allerginicity of isolated cow's milk and soy proteins, 2013, 28, 815.

  • Ramaswamy, R., Balasubramaniam, V.M. and Kaletunc, G. High Pressure Processin. OSU Fact Sheet for Food Processors. Available online: http://ohioline.osu.edu/fse-fact/ 0001.html.

  • Huppertz, T., Fox, P. and Kelly, A. High pressure induced denaturation of α-lactalbumin and α-lactoglobulin in bovine milk and whey: a possible mechanism. J. Dairy. Res., 2004, 71, 489-495.

  • Montenegro, J., Ruan, R., Ma, H. and Chen, P. Inactivation of E.coli 0157:H7 using a pulsed non-thermal plasma system. J. Fd. Sci., 2002, 67, 646-648.

  • Akitsu, T., Ohkawa, H., Tsuji, M., Kimura, H. and Kogoma, M. Plasma sterilization using glow discharge at atmospheric pressure. Surf. Coat. Technol. 2005, 193, 29-34.

  • Deng, S., Ruan, R., Mok, C.K., Huang, G., Lin, X. and Chen, P. Inactivation of Escherichia coli on almonds using non-thermal plasma. J. Fd. Sci., 2007, 72, 62-6.

  • Laroussi, M. Non-thermal decontamination of biological media by atmospheric-pressure plasmas: review, analysis and prospects. IEEE Trans. Plasma Sci., 2002, 30, 1409-1415.

  • Laroussi, M. Low temperature plasma-based sterilization: overview and state of the art. Plasma Process. Polym., 2005, 2, 391-400.

  • Goldson, R.J. and Rutherford, P.H. Introduction to plasma physics. Institute of Physics Publishing, Ltd., Bristol, UK. 1995.

  • Hengel Arjon, J. and van. Food allergen detection methods and the challenge to protect food-allergic consumers. Anal. Bioanal. Chem., 2007, 389, 111-118.

  • Besler, M. Determination of allergens in foods. Trends. Ana. Chem., 2001, 20, 662-672.

  • Sampson, H.A. Food allergy. Part 1: Immunopathogenesis and clinical disorders. J. Allergy. Clin. Immunol., 1999, 103, 717-28.

  • Merget, R., Stollfuss, J., Wiewrodt, R., Fruhauf, H. and Koch, U. Diagnostic tests in enzyme allergy. J. Allergy. Clin. Immunol., 1993, 92, 264-277.

  • Wachholz, P., Dearman, R. and Kimber, I. Detection of allergen-specific IgE antibody responses. J. Immunotoxicol., 2005, 1, 189-199.

  • Towbin, H., Staehelin, T. and Gordon, J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. U.S.A. 1979, 76, 4350-4354.

  • Singh, M. and Knox, R. Grass pollen allergens: antigenic relationships detected using monoclonal antibodies and dot blotting immunoassay. Int. Arch. Allergy. Immunol., 1985, 78, 300-304.

  • Shapiro, A., Vinuela, E. and Maizel Jr, J. Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels. Biochem. Biophys. Res. Commun. 1967, 28, 815.

  • Kumar, T.K., Gopalakrishna, K., Prasad, V.V. and Pandit, M.V. Multiple bands on the sodium dodecyl sulfate - polyacrylamide gel electrophoresis gels of proteins due to intermolecular disulfide cross-linking. Anal Biochem., 1993, 213, 226-228.

  • Taheri-Kafrani, A., Gaudin, J.C., Rabesona, H., Nioi, C., Agarwal, D., Drouet, M., Chobert, J.M., Bordbar, A.K. and Haertlft, T. Effects of heating and glycation of betalactoglobulin on its recognition by IgE of sera from cow milk allergy patients. J. Agri. Fd. Chem., 2009, 57, 4974-4982.

  • Wuthrich, K. NMR of Proteins and Nucleic acids. 1st Edition. John Wiley & Sons, U.S.A.1986.

  • Belloque, J. High-resolution NMR of milk and milk proteins. Modern Magnetic Resonance.2008, 1631-1635.

  • Goetz Joachim, Peter Koehler. Study of the thermal denaturation of selected proteins of whey and egg low resolution NMR. Fd. Sci. Technol., 2005, 38, 501-512.

  • Eads, T.M. and Bryant, R.G. High resolution proton NMR spectroscopy of milk, orange juice and apple juice with efficient suppression of the water peak. J. Agri. Fd. Chem., 1986, 34, 834-837.

  • Belton, P.S., Delgadillo, I., Holmes, E., Nicholls, A., Nocholson, J.K. and Spraul, M. Use of high-field 1H NMR spectroscopy for the analysis of liquid foods. J. Agri. Fd. Chem., 1996, 44, 1483-1487.

  • Shefcheck, K.J., Callahan, J.H. and Musser, S.M. Confirmation of peanut protein using peptide markers in dark chocolate using liquid chromatography-tandem mass spectrometry (LC-MS/MS). J. Agri. Fd. Chem. 2006, 54, 7953-7959.

  • Jiang, D., Ji, J., An, J., Sun, X., Zhang, Y., Zhang, G. and Tang, L. Mast cell-based electrochemical biosensor for quantification of the major shrimp allergen Pena1 (tropomyosin). Biosensors and Bioelectronics. 2013, 50, 150-156.

  • Tran, D.T., Knez, K., Janssen, K.P., Pollet, J., Spasic, D. and Lammertyn, J. Selection of aptamers against Ara h 1 protein for FO-SPR biosensing of peanut allergens in food matrices. Biosensors and Bioelectronics, 2013, 43, 245-25.

  • Sun, X., Guan, L., Shan, X., Zhang, Y. and Li, Z. Electrochemical detection of peanut allergen ara h 1 using a sensitive DNA biosensor based on stem-loop probe. J. Agri. Fd. Chem., 2012, 60, 10979-10984.

  • Wang, W., han, J., Wu, Y., Yuan, F., Chen, Y. and Ge, Y. Simultaneous detection of eight food allergens using optical thin-film biosensor chips. J. Agri. Fd. Chem., 2011, 59, 6889-6894.

  • Herrero, B., Vieites, J.M. and Espineira, M. Development of an in-house fast real-time PCR method for detection of fish allergen in foods and comparison with a commercial kit. Fd. Chem., 2014, 151, 415-420.

  • Lopez-Calleja, I.M., de la Cruz, S., Gonzalez, I., GarcIa, T. and MartIn, R. Survey of undeclared allergenic pistachio (Pistacia vera) in commercial foods by hydrolysis probe real-time PCR. Fd. Contl., 2014, 39, 49-55.

  • Lopez-Calleja, I.M., de la Cruz, S., Pegels, N.,Gonzalez, I., Martin, R. and GarcIa, T. LWT - Fd. Sci. Technol., 2014, 56, 31-39.


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  • Advances in Non Thermal Processing for Reducing Dairy and Food Allergenicity

Abstract Views: 381  |  PDF Views: 2

Authors

V. Dhineshkumar
Department of Food science and Technology, College of Food and Dairy Technology, Chennai, India
D. Ramasamy
Department of Food science and Technology, College of Food and Dairy Technology, Chennai, India

Abstract


More than 160 food materials are identified as allergens. However, 90% of allergic reactions are caused by eight major food allergens. Food Allergen Labelling and Consumer Protection Act (FALCPA) of 2004 came into effect from January 1, 2006. This law requires the identification of ingredients derived from the major food allergens, on the food label. Several research efforts are ongoing to develop hypoallergenic foods. In this article, recent status of food allergy and studies reporting advanced processing technologies for reducing allergenicity of foods are reviewed. A brief survey of methods of allergen detection has been also reported as measures to control allergens in food industry.

Keywords


Food Allergy, Non-Thermal Processing, High Intensity Ultrasound, Non-Thermal Plasma, Ultraviolet Light, High Pressure Processing.

References